Skin Beautiful Dermaceuticals

How to Save Face

Free radicals have become a household word. Scores of people take Vitamin C, a potent and proven antioxidant, for its free radical squenching abilities, in an attempt to live better and longer.  But what about our skin? Can we apply something like Vitamin C directly to our skin for even further protection? The answer is a resounding YES.

The fact is that skin is damaged by excessive production of free radicals. Free radicals form in skin upon ultraviolet exposure (read: sun exposure).  Acute and chronic photo radiation damage depletes the body’s natural antioxidant enzyme systems and increases oxidative protein modifications (cross-links). These pathological effects are found in the upper and lower layers of the skin. Cross-linked (glycated) proteins are classic characteristics of skin aging. Cross-linked proteins in the skin result in stiffening, wrinkling and the unsightly leathery appearance.


The effect of exposure to even ambient UV-irradiation increases the risk for long term detrimental effects characterized by wrinkles, loss of skin tone and resilience. Photoaged skin displays prominent alterations in the cellular component and the extra cellular matrix of the connective tissue. UV-exposure results in an accumulation of disorganized elastin and a severe loss of collagens, the major structural proteins of the dermal connective tissue. The unifying pathogenic agents for these changes are UV-generated free radicals. As well as causing permanent gene mutations, free radicals activate signal transduction pathways that are related to growth, differentiation, senescence and connective tissue degradation.

One study found that pro-oxidative factors that accelerate skin aging might activate a self-maintained micro-inflammatory process that interferes with skin elasticity and thickness.

Well, that didn’t sound good, did it? You probably just put your bathing suit away and hid in a shady spot. So is there anything we can do to protect ourselves from free radical damage and skin aging without becoming a hermit? Thankfully, the answer to this one is also YES. In fact, the same study that determined that free radicals result in inflammation and skin aging went on to say that topical antioxidants decrease this inflammatory cascade and thus afford protection to the skin structures.

Protecting against these free radical insults is actually a proven way to slow the effects of aging. Recently published papers confirm that a decline in natural antioxidant systems is a key factor responsible for the unsightly appearance of aged skin. The skin, as the outermost barrier of the body, is exposed to various sources of oxidative stress, in particular UV-irradiation and environmental toxins such as cigarette smoke, air pollution, etc. Internally, the skin is attacked like any other organ, through processes involving glycation (protein cross-linking), collagen-elastin degradation and free radical-induced injury. One way of mitigating this process is by direct topical application of antioxidants. Indeed, various animal and human studies have proved that topically applied antioxidants exert protective effects against free radical damage (oxidative stress).

Critics used to claim there was no evidence that topically based products affected skin aging. Over the past three years, a remarkable number of published studies have proven these skeptics wrong! If you type “topical antioxidants and skin” into, you’ll easily find of plethora of scientific studies to back up the use of Vitamin C as a skin saver and rejuvenator. The science clearly substantiates the role that free radicals play in causing skin aging and the fact that topically applied antioxidants confer significant protection and can even partially reverse some aspects of skin aging.

Skin Beautiful Dermaceuticals uses three of most stable forms of Vitamin C available in its Best Defense Serum.


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